[The efficacy of creatine phosphate in the treatment of patients with heart failure. Its echographic evaluation after acute and protracted treatment].

Abstract

The hemodynamic effects of acute and long-term administration of creatine phosphate were studied in 23 patients with heart failure (NYHA classes II and III) under stabilized treatment. Acute creatine phosphate (5 g i.v.) induced a significant increase of the ejection fraction (FE) and of other parameters of cardiac contractility. Once these improvements of cardiac contractility were obtained by acute treatment, further significant increases in cardiac function were observed if treatment was continued for six days, i.e. telesystolic diameter and volume, as well as parietal stress were significantly reduced, and ejection fraction and shortening fraction were significantly increased. Creatine phosphate treatment has a favourable influence on the hemodynamics of patients with an obvious contractility deficit and chronic ischemia of the myocardium.

• Authors: M Cafiero, E Strumia, S Pirone, S Pacileo, R Santoro
• Journal: La Clinica terapeutica (Clin Ter) Vol. 144 Issue 4 Pg. 321-8 (Apr 1994) ISSN: 0009-9074 [Print] Italy
• Vernacular Title: Efficacia della creatina fosfato nel trattamento dei pazienti con insufficienza cardiaca. Valutazione ecocardiografica dopo trattamento acuto e protratto.
• PMID: 8205755 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Phosphocreatine

Topics

• Acute Disease
• Aged
• Cardiomyopathy, Dilated (complications, diagnostic imaging, drug therapy)
• Chronic Disease
• Drug Evaluation
• Echocardiography (drug effects)
• Female
• Heart Failure (diagnostic imaging, drug therapy, etiology, physiopathology)
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged
• Myocardial Ischemia (complications, diagnostic imaging, drug therapy)
• Phosphocreatine (therapeutic use)