Abstract | BACKGROUND: METHODS AND RESULTS: ADR was administered to rats in six equal intraperitoneal injections over a period of 2 weeks (cumulative dose of 15 mg/kg). After a 3-week posttreatment period, cardiomyopathy and congestive heart failure were characterized by ascites, congested liver, depressed cardiac function, elevated left ventricular end-diastolic pressure, and myocardial cell damage. Myocardial glutathione peroxidase (GSHPx) activity was decreased, and lipid peroxidation was increased. Probucol (cumulative dose, 60 mg/kg IP) was administered in six equal injections over a 2-week period on days alternating with ADR treatment. Probucol significantly attenuated the myocardial effects of ADR, improved left ventricular function, and lowered mortality as well as the amount of ascites. Treatment with probucol was also accompanied by an increase in myocardial GSHPx and superoxide dismutase activities, with a concomitant decrease in lipid peroxidation. CONCLUSIONS:
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Authors | N Siveski-Iliskovic, N Kaul, P K Singal |
Journal | Circulation
(Circulation)
Vol. 89
Issue 6
Pg. 2829-35
(Jun 1994)
ISSN: 0009-7322 [Print] United States |
PMID | 8205698
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Doxorubicin
- Glutathione Peroxidase
- Superoxide Dismutase
- Probucol
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Topics |
- Animals
- Antioxidants
(metabolism)
- Doxorubicin
(toxicity)
- Glutathione Peroxidase
(metabolism)
- Heart Failure
(chemically induced, prevention & control)
- Hemodynamics
(drug effects)
- Lipid Peroxidation
- Male
- Myocardium
(metabolism, ultrastructure)
- Probucol
(pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(metabolism)
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