Abstract | BACKGROUND: Recent reports suggest that adenosine, in addition to terminating supraventricular tachycardia involving the atrioventricular (AV) node, may have antiarrhythmic effects on atrial tachycardia. The electrophysiological effects of adenosine on supraventricular tissue include shortening of action potential duration in atrial myocytes mediated by the potassium current, IKACh, Ado; shortening of action potential duration and hyperpolarization in sinus node cells; and anti- adrenergic electrophysiological effects resulting from inhibition of adenylyl cyclase. We therefore hypothesized that the response of atrial tachycardia to adenosine would be mechanism specific, with termination of atrial tachycardia due to sinus node reentry or cAMP-mediated triggered activity, transient suppression of automatic atrial tachycardia, and an absence of antiarrhythmic effect on tachycardia due to intraatrial reentry. METHODS AND RESULTS: CONCLUSIONS: These findings demonstrate that adenosine's effects on atrial tachycardia are mechanism specific and can be used to differentiate between reentrant tachycardia confined to the region of the sinus node or atria and between nonreentrant atrial tachycardia due to either triggered activity or automaticity.
|
Authors | E D Engelstein, N Lippman, K M Stein, B B Lerman |
Journal | Circulation
(Circulation)
Vol. 89
Issue 6
Pg. 2645-54
(Jun 1994)
ISSN: 0009-7322 [Print] United States |
PMID | 8205677
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Adenosine
(pharmacology, therapeutic use)
- Adolescent
- Adult
- Aged
- Atrial Flutter
(drug therapy)
- Electrocardiography
- Female
- Humans
- Male
- Middle Aged
- Sinoatrial Node
(drug effects)
- Tachycardia
(drug therapy, etiology, physiopathology)
- Tachycardia, Sinoatrial Nodal Reentry
(drug therapy)
|