Expression of insulin-like growth factor II by a gastric carcinoma associated with hypoglycaemia.

Abstract

A gastric cancer with liver metastases was associated with low morning levels of plasma glucose (24 mg/dl), insulin (< 2.5 microU/ml) and growth hormone (0.23 ng/ml). Primary and metastatic tumour tissue stained positively with anti-insulin-like growth factor II (IGF-II) monoclonal antibody. Western immunoblot analysis revealed a high molecular weight IGF-II in the serum: 15 kDa (normal: 7.5 kDa). Postmortem reverse transcription polymerase chain reaction on mRNA from both sites revealed 471 base pairs size cDNA encoding prepro-IGF-II. These results suggest that the gastric carcinoma encoded, expressed, and secreted IGF-II, probably causing the extrapancreatic tumour hypoglycaemia.

• Authors: T Horiuchi, Y Shinohara, Y Sakamoto, N Hizuka, T Watabe, O Mokuda, K Tanaka, N Shimizu, I Sugano, K Nagao
• Journal: Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 424 Issue 4 Pg. 449-52 ( 1994) ISSN: 0945-6317 [Print] Germany
• PMID: 8205358 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insulin-Like Growth Factor II

Topics

• Aged
• Aged, 80 and over
• Base Sequence
• Blotting, Western
• Humans
• Hypoglycemia (complications)
• Insulin-Like Growth Factor II (metabolism)
• Liver Neoplasms (secondary)
• Male
• Molecular Sequence Data
• Polymerase Chain Reaction
• Stomach Neoplasms (complications, metabolism, pathology)