Abstract |
Although great advances have been made in the operative treatment of vascular disorders, the management of most venous problems is still nonsurgical. Daflon 500 mg* is a micronized flavonoid mixture of 90% diosmin and 10% hesperidin that has phlebotonic properties. The efficacy of Daflon 500 mg has been investigated in three double-blind, randomized trials using strain gauge plethysmography to provide quantitative information on venous hemodynamics in patients with chronic venous insufficiency. In total, 183 patients were treated with Daflon 500 mg versus a control group of equal number of patients. Daflon 500 mg produced a significant decrease in venous capacitance, venous distensibility, and venous emptying time (P < 0.001). In addition, these changes were accompanied by improvement in clinical symptoms and a decrease in the supramalleolar circumference. Clinical side effects were rare and led to treatment withdrawal in only 3 patients. It is concluded that Daflon 500 mg is of benefit to patients with chronic venous insufficiency.
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Authors | G Geroulakos, A N Nicolaides |
Journal | Angiology
(Angiology)
Vol. 45
Issue 6 Pt 2
Pg. 549-53
(Jun 1994)
ISSN: 0003-3197 [Print] United States |
PMID | 8203786
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Drug Combinations
- Flavonoids
- S 5682
- Diosmin
- Hesperidin
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Topics |
- Diosmin
(therapeutic use)
- Drug Combinations
- Flavonoids
(therapeutic use)
- Hesperidin
(therapeutic use)
- Humans
- Plethysmography
- Randomized Controlled Trials as Topic
- Venous Insufficiency
(diagnosis, drug therapy)
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