Flavonoids. A review of the pharmacology and therapeutic efficacy of Daflon 500 mg in patients with chronic venous insufficiency and related disorders.

Abstract

Daflon 500 mg consists of 450 mg diosmin and 50 mg flavonoid expressed as hesperidin. The authors describe its effects on the microcirculation in chronic venous insufficiency: improvement of venous tone, inhibition of prostaglandin synthesis, protection against free radicals, activation of the complement system, and increased lymphatic drainage. The authors summarize studies of its therapeutic efficacy in reducing venous capacitance, distensibility, and emptying time; reducing capillary permeability; and increasing capillary resistance.

• Authors: J R Struckmann, A N Nicolaides
• Journal: Angiology (Angiology) Vol. 45 Issue 6 Pg. 419-28 (Jun 1994) ISSN: 0003-3197 [Print] United States
• PMID: 8203767 (Publication Type: Journal Article, Review)

Chemical References

• Drug Combinations
• Flavonoids
• S 5682
• Diosmin
• Hesperidin

Topics

• Animals
• Chronic Disease
• Diosmin (pharmacology, therapeutic use)
• Drug Combinations
• Flavonoids (pharmacology, therapeutic use)
• Hesperidin (pharmacology, therapeutic use)
• Humans
• Venous Insufficiency (drug therapy)