Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS:
Infarct volume of animals that received the MDL-100,453 bolus injection followed by MDL-100,453 infusion was significantly smaller than that of controls (P < .01). A significant effect of infusion on the reduction of extent of infarct size was also demonstrated (P = .015). Moreover, a statistically significant inverse correlation was demonstrated between the infarct volume and blood levels of MDL-100,453 at 60 minutes and 120 minutes after injection (r = -.33 and r = -.49, respectively). CONCLUSIONS:
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Authors | Y Hasegawa, M Fisher, B M Baron, G Metcalf |
Journal | Stroke
(Stroke)
Vol. 25
Issue 6
Pg. 1241-4; discussion 1245-6
(Jun 1994)
ISSN: 0039-2499 [Print] United States |
PMID | 8202987
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Placebos
- 4-oxo-5-phosphononorvaline
- Carbon Dioxide
- N-Methylaspartate
- Valine
|
Topics |
- Animals
- Blood Pressure
(physiology)
- Body Temperature
(drug effects)
- Brain
(drug effects, physiology)
- Carbon Dioxide
(blood)
- Cerebral Arteries
- Cerebral Infarction
(blood, pathology, prevention & control)
- Infusion Pumps
- Injections, Intravenous
- Ischemic Attack, Transient
(blood, physiopathology, prevention & control)
- Male
- N-Methylaspartate
(administration & dosage, antagonists & inhibitors, blood, therapeutic use)
- Pilot Projects
- Placebos
- Rats
- Rats, Sprague-Dawley
- Valine
(administration & dosage, analogs & derivatives, blood, therapeutic use)
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