[The use of streptokinase preparations in pleural empyema and pyopneumothorax].

Abstract

Prevailing fibrin-formation in the pleural cavity entails hypoactivity of trypsin-like proteinases and a high inhibitory potential in the serum and pleural exudate. Streptokinase preparations appeared an effective means of pharmacological pulmonary decortication in patients with high pleural levels of plasminogen. The authors obtained higher efficacy of conservative therapy for pyothorax when they used a specially designed technique of intrapleural administration of streptokinase-activated fresh frozen plasma of the same group. The outcomes of the disease were also improved noticeably.

• Authors: Ia N Shoĭkhet, O G Ogloblina, E A Tseĭmakh, T D Mal'chenko
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 66 Issue 3 Pg. 64-7 ( 1994) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Primenenie preparatov streptokinazy pri émpieme plevry i piopnevmotorakse.
• PMID: 8202857 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Protease Inhibitors
• Peptide Hydrolases
• Streptokinase

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Empyema, Pleural (drug therapy, enzymology)
• Female
• Humans
• Male
• Middle Aged
• Peptide Hydrolases (analysis, drug effects)
• Plasma
• Pleural Effusion (drug therapy, enzymology)
• Pneumothorax (drug therapy, enzymology)
• Protease Inhibitors (analysis)
• Streptokinase (administration & dosage)