Abstract |
The clastogenic effects of N-nitrosodimethylamine (N-DMA) and dinitrosoglycolurile ( DNSGU) were studied in the bone marrow of mice and in peripheral blood lymphocytes of cows. None of the tested compounds showed significant enhancement of chromosome aberrations at doses 1/2 LD50 and 1/10 LD50 in murine bone marrow cells. Treatment of cow peripheral blood lymphocytes with N-DMA at concentration of 6 x 10(-5) mol/l (or 12 x 10(-5) mol/l for DNSGU) produced statistically significant increase of chromosomal breaks. The clastogenic effect was also observed in cultures treated with DNSGU at the highest tested concentration (12 x 10(-4) mol/l), but the exposure to N-DMA at parallel concentration had a toxic effect. At the lowest doses of N-DMA and DNSGU (6 x 10(-6) and 12 x 10(-6) mol/l, respectively) no clastogenic effect was obtained.
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Authors | K Siviková |
Journal | Neoplasma
(Neoplasma)
Vol. 41
Issue 1
Pg. 21-4
( 1994)
ISSN: 0028-2685 [Print] Slovakia |
PMID | 8202190
(Publication Type: Journal Article)
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Chemical References |
- Imidazoles
- Mutagens
- Nitroso Compounds
- dinitrosoglycolurile
- Dimethylnitrosamine
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Topics |
- Animals
- Bone Marrow Cells
- Cattle
- Chromosome Aberrations
- Dimethylnitrosamine
(toxicity)
- Imidazoles
(toxicity)
- Lymphocytes
(ultrastructure)
- Male
- Mice
- Mice, Inbred ICR
- Mutagens
- Nitroso Compounds
(toxicity)
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