Abstract | PURPOSE: PATIENTS AND METHODS: Between January 1977 and June 1988, 468 patients entered this randomized study and 317 were considered eligible. Following complete surgical resection with or without radiotherapy, outcome in 145 eligible patients receiving cyclophosphamide 500 mg/m2 intravenously (IV) bolus on day 1, vincristine 1.4 mg/m2 IV bolus on day 1, doxorubicin ( Adriamycin; Adria Laboratories, Columbus, OH) 50 mg/m2 IV bolus on day 1, and dacarbazine ( DTIC) 400 mg/m2 by 1-hour infusion on days 1 to 3 ( CYVADIC) cycles repeated every 28 days for eight courses was compared with that in 172 control patients. RESULTS: With a median follow-up duration of 80 months (range, 39 to 165), actuarial percentage survival figures at 7 years were compared. Relapse-free survival rates were higher for CYVADIC, 56% versus 43% (P = .007), and local recurrence was significantly reduced in the CYVADIC arm at 17% versus 31% (P = .004). In contrast, distant metastases occurred with similar frequency in both arms, 32% for CYVADIC versus 36% for control patients (P = .42), and overall survival rates were not significantly different at 63% versus 56% (P = .64). A reduction in local recurrence was only apparent in the group of head, neck, and trunk sarcomas (P = .002), but not in limb tumors (P = .31). CONCLUSION:
|
Authors | V Bramwell, J Rouesse, W Steward, A Santoro, H Schraffordt-Koops, J Buesa, W Ruka, J Priario, T Wagener, M Burgers |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 12
Issue 6
Pg. 1137-49
(Jun 1994)
ISSN: 0732-183X [Print] United States |
PMID | 8201375
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Vincristine
- Dacarbazine
- Doxorubicin
- Cyclophosphamide
|
Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemotherapy, Adjuvant
- Cyclophosphamide
(administration & dosage)
- Dacarbazine
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Sarcoma
(drug therapy, mortality, pathology, therapy)
- Soft Tissue Neoplasms
(drug therapy, mortality, pathology, therapy)
- Survival Rate
- Vincristine
(administration & dosage)
|