[Quantitative analysis of six lectin receptors and its application in differential diagnosis of astrogliomas and reactive hyperplasia of gliocytes].

Abstract

The distribution of six lectin receptors (WGA, RCA-1, LCA, PSA, PNA, SBA) in 71 human astrogliomas, 8 human normal brain tissues and 11 reactive hyperplasia of gliocytes was examined by avidin-biotin-peroxidase technique and quantified with an image analysis. The results showed that WGA and RCA-1 may be used as good markers for distinguishing well differentiated astrocytomas from reactive hyperplasia of gliocytes. The quantities of LCA and PSA receptors of astrocytomas with different degree of differentiation were different. Expression of SBA and PNA receptors in normal brain tissues and different lesions was similar. The results suggest that glycoproteins and glycolipids with N-glucosidic bonds mainly changed in the process of histogenesis and differentiation of astrocytomas.

• Authors: S M Yang
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 15 Issue 6 Pg. 403-7 (Nov 1993) ISSN: 0253-3766 [Print] China
• PMID: 8200274 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Plant Proteins
• Receptors, Mitogen
• Ricinus communis lectin receptor
• Wheat Germ Agglutinins
• wheat germ agglutinin receptor
• Ricin

Topics

• Astrocytes (pathology)
• Astrocytoma (chemistry, diagnosis)
• Biomarkers, Tumor (analysis)
• Brain (metabolism)
• Diagnosis, Differential
• Glioblastoma (chemistry, diagnosis)
• Humans
• Hyperplasia
• Image Processing, Computer-Assisted
• Plant Proteins (analysis)
• Receptors, Mitogen (analysis)
• Ricin
• Wheat Germ Agglutinins (analysis)