Native valve endocarditis due to Candida parapsilosis: a late complication after bone marrow transplantation-related fungemia.

Abstract

A case of Candida parapsilosis endocarditis observed 16 months after BMT is reported. The patient, a 35-year-old female with CML, suffered from Candida parapsilosis fungemia on day +22 after BMT. In spite of treatment with amphotericin B, fluconazole and catheter withdrawal, the same yeast was isolated > 1 year later from a vegetation on an old rheumatic mitral valve. Although the patient remained in complete cytogenetical and hematological remission, in vitro tests showed reduced phagocytic and chemotactic capacity of neutrophils and monocytes. This case stresses the need of prolonged therapy for patients with candidemia after BMT.

• Authors: J A Cancelas, J Lopez, E Cabezudo, E Navas, J Garcia Laraña, M Jimenez Mena, P Diz, J Perez de Oteyza, L Villalon, A Sanchez-Sousa
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 13 Issue 3 Pg. 333-4 (Mar 1994) ISSN: 0268-3369 [Print] England
• PMID: 8199575 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amphotericin B
• Fluconazole

Topics

• Adult
• Amphotericin B (therapeutic use)
• Bone Marrow Transplantation (adverse effects)
• Candida
• Candidiasis (complications, drug therapy, etiology)
• Endocarditis (etiology, pathology)
• Female
• Fluconazole (therapeutic use)
• Fungemia (complications, drug therapy, etiology)
• Heart Valve Diseases (etiology, pathology)
• Humans
• Mitral Valve (microbiology, pathology)
• Recurrence