Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms.

Cerebrospinal fluid (CSF) from 8 patients with symptomatic infantile spasms was collected before specific treatment for infantile spasms. The concentration of CSF kynurenic acid (KYA) and 3-hydroxykynurenine (3-OHKY) in infantile spasms was analyzed by high-performance liquid chromatography and compared with CSF KYA from 10 age-matched controls. The levels of CSF KYA were significantly lower in infantile spasm patients compared to controls (P < .05). In contrast, the levels of CSF 3-OHKY were significantly higher in infantile spasm patients than in controls (P < .05). These findings suggest that the presence of seizures in infantile spasms is associated with altered metabolism of 3-OHKY. The possibility that seizures may be related to increased or decreased production of certain kynurenine metabolites is discussed.
AuthorsH Yamamoto, I Shindo, B Egawa, K Horiguchi
JournalPediatric neurology (Pediatr Neurol) Vol. 10 Issue 1 Pg. 9-12 (Feb 1994) ISSN: 0887-8994 [Print] UNITED STATES
PMID8198681 (Publication Type: Journal Article)
Chemical References
  • Kynurenine
  • 3-hydroxykynurenine
  • Kynurenic Acid
  • Asphyxia Neonatorum (cerebrospinal fluid, diagnosis)
  • Brain (physiopathology)
  • Chromatography, High Pressure Liquid
  • Electroencephalography
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Kynurenic Acid (cerebrospinal fluid)
  • Kynurenine (analogs & derivatives, cerebrospinal fluid)
  • Male
  • Spasms, Infantile (cerebrospinal fluid, diagnosis)
  • Synaptic Transmission (physiology)
  • Tuberous Sclerosis (cerebrospinal fluid, diagnosis)

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