Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats.

Abstract

Hypothalamic concentration of neuropeptide Y was decreased significantly in anorectic tumor-bearing rats, while NPY level was increased significantly in matched carcass weight control rats as compared with freely-feeding controls. In vivo microdialysis of the perifornical hypothalamic area of tumor-bearing rats prior to the development of anorexia revealed no alteration in NPY in dialysates. Following the development of anorexia, however, tumor-bearing rats exhibited significant reduction in NPY concentration in dialysates as compared with either matched carcass weight or freely-feeding control group. These results suggest that hypothalamic NPY concentration and release are decreased selectively in anorectic tumor-bearing rats. Since NPY also elicits less feeding in tumor-bearing rats, dysfunction of hypothalamic NPY feeding mechanisms may be of primary importance in cancer anorexia.

• Authors: W T Chance, A Balasubramaniam, R Dayal, J Brown, J E Fischer
• Journal: Life sciences (Life Sci) Vol. 54 Issue 24 Pg. 1869-74 ( 1994) ISSN: 0024-3205 [Print] Netherlands
• PMID: 8196504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Neuropeptide Y

Topics

• Animals
• Anorexia (metabolism)
• Hypothalamus (chemistry, metabolism)
• Male
• Microdialysis
• Neoplasms, Experimental (metabolism)
• Neuropeptide Y (analysis, metabolism)
• Rats
• Rats, Inbred F344