Abstract | BACKGROUND: METHODS: RESULTS:
Pholedrine dilates the normal pupil by 2.2 mm (mean). It acts at the longest 8-10 hours with maximal effect between 20 and 90 minutes. After this period its effect decreases rapidly. It acts independently from age and from baseline pupil diameter. Given repeatedly the second administration reaches the same mydriatic effect as the first only if the interval between both applications is 72 hours or more. This is because it needs some time to refill the noradrenaline stores in the sympathetic neuron innervating the dilator muscle of the pupil. In Horner's syndrome pholedrine dilates the involved pupil only minimally in case of a postganglionic lesion, and in case of a preganglionic lesion it dilates the pupil even slightly more than the normal fellow pupil. It shows the same effect as hydroxyamphetamine. There are only few side effects. CONCLUSION:
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Authors | H Wilhelm, E Schäffer |
Journal | Klinische Monatsblatter fur Augenheilkunde
(Klin Monbl Augenheilkd)
Vol. 204
Issue 3
Pg. 169-75
(Mar 1994)
ISSN: 0023-2165 [Print] Germany |
Vernacular Title | Pholedrin zur Lokalisation des Horner-Syndroms. |
PMID | 8196303
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Ophthalmic Solutions
- Sympathomimetics
- Methamphetamine
- pholedrine
- Norepinephrine
|
Topics |
- Adolescent
- Adult
- Aged
- Autonomic Fibers, Postganglionic
(drug effects, physiology)
- Autonomic Fibers, Preganglionic
(drug effects, physiology)
- Child
- Female
- Ganglia, Sympathetic
(drug effects, physiopathology)
- Horner Syndrome
(diagnosis, physiopathology)
- Humans
- Male
- Methamphetamine
(analogs & derivatives)
- Middle Aged
- Nerve Endings
(drug effects, physiology)
- Norepinephrine
(physiology)
- Ophthalmic Solutions
- Reference Values
- Reflex, Pupillary
(drug effects, physiology)
- Sympathomimetics
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