Brodimoprim is a long acting broad spectrum
antibacterial agent. It is a new selective inhibitor of bacterial
dihydrofolate reductase, structurally related to
trimethoprim. The aim of the present study was to investigate the efficacy and tolerability of
brodimoprim (10 mg/kg on the first day, 5 mg/kg/die onward) in the treatment of
upper respiratory tract infections in children (age range: 2-14 years). This open group comparative study was performed either in 68 children affected by bacterial pharyngotonsillitis (37 treated with
brodimoprim, 31 with
erythromycin 560 mg/kg/8 hours) or in 50 patients affected by
otitis media (25 treated with
brodimoprim, 25 with
amoxicillin/clavulanic acid 50 mg/kg/12 hours) or in 52 patients affected by acute
sinusitis (25 treated with
brodimoprim, 27 with
amoxicillin/clavulanic acid 50 mg/kg/12 hours). All patients were clinically evaluated before admission, during the trial and 48 hours after the last dose of
antibiotic. At the same time blood and secretion samples were collected for hematology/biochemistry and microbiological assays. A total of 170 subjects were treated and 141 patients demonstrated a clinical recovery/improvement following the treatment period, with approximately the same recovery rate (83%) among the groups. The bacteriological response was evaluated in 169 subjects. Eradication of pathogens was documented in 27 subjects treated with
brodimoprim and 28 with
erythromycin in the pharyngotonsillitis group, in 22 subjects treated with
brodimoprim and 16 with
amoxicillin/clavulanic acid in the
otitis group and in 17 subjects treated with
brodimoprim and 20 with
amoxicillin/clavulanic acid in the
sinusitis group. The overall eradication in
brodimoprim treated patients was 77% in comparison with 76% of eradication obtained in the control groups.(ABSTRACT TRUNCATED AT 250 WORDS)