Abstract |
Eighty adult patients affected by acute bacterial otitis media were selected and randomized into two balanced groups of treatment: 1) brodimoprim 200 mg tablets at the dosage of 2 tablets in single dose on the first day and one tablet on the following days; 2) josamycin 500 mg tablets at the dosage of 3 tablets/day. The average duration of treatment was 8 days: all patients completed the trial. The symptoms were evaluated by score method (on the 3rd, 7th and on the last day of therapy) and a thermometric curve was made daily. Microbiological examination of the exudate was performed in the patients with auricular discharge (28), at the beginning of the treatment and 7 days after the end of therapy. The tolerability was assessed through registration of side effects. Brodimoprim resulted more effective in the reduction of hypoacusis and tinnitus; other symptoms demonstrated higher percentage reductions in the group under brodimoprim therapy. Bacteriological exams were negative at the second checkup, except in 6 patients (3 per group). Side effects were reported in 5 patients (12.5%) treated with brodimoprim and in 9 (22.5%) treated with josamycin. Abnormal values in laboratory tests were not observed.
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Authors | E De Campora, M Radici, A Camaioni |
Journal | Journal of chemotherapy (Florence, Italy)
(J Chemother)
Vol. 5
Issue 6
Pg. 529-31
(Dec 1993)
ISSN: 1120-009X [Print] England |
PMID | 8195851
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Trimethoprim
- Josamycin
- brodimoprim
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Bacterial Infections
- Drug Tolerance
- Exudates and Transudates
(microbiology)
- Female
- Humans
- Josamycin
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Otitis Media
(drug therapy, microbiology)
- Trimethoprim
(analogs & derivatives, pharmacology, therapeutic use)
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