Abstract |
This case report describes the first established pregnancy and birth after induction of ovulation with recombinant human follicle-stimulating hormone (FSH) in a woman suffering from chronic clomiphene-resistant anovulation due to polycystic ovary syndrome (elevated serum luteinizing hormone and testosterone concentrations together with polycystic ovaries). Starting on day 3 of a progestagen withdrawal bleeding, 75 IU of rFSH was administered i.m. daily until a single preovulatory follicle was seen upon transvaginal ultrasound examination at day 13. Ovulation was induced by a single i.m. administration of 10,000 IU of human chorionic gonadotrophin, after which a viable singleton pregnancy was revealed at a gestational age of 6 weeks. The course of pregnancy and labour was uneventful and no abnormalities were found upon a paediatric examination.
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Authors | H J van Dessel, P F Donderwinkel, H J Coelingh Bennink, B C Fauser |
Journal | Human reproduction (Oxford, England)
(Hum Reprod)
Vol. 9
Issue 1
Pg. 55-6
(Jan 1994)
ISSN: 0268-1161 [Print] England |
PMID | 8195351
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Recombinant Proteins
- Follicle Stimulating Hormone
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Topics |
- Female
- Follicle Stimulating Hormone
(therapeutic use)
- Humans
- Infertility, Female
(drug therapy, etiology)
- Ovulation Induction
(methods)
- Polycystic Ovary Syndrome
(complications)
- Pregnancy
- Pregnancy Outcome
- Recombinant Proteins
(therapeutic use)
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