Antitumor effect of piericidin B1 N-oxide.

Abstract

Piericidin B1 N-oxide was isolated from a culture broth of Streptomyces sp. as a novel inhibitor of phosphatidylinositol (PI) turnover. Piericidin B1 N-oxide specifically inhibited orthophosphate labeling of PI induced by epidermal growth factor (EGF) without affecting the formation of phosphatidic acid (PA). Like piericidins A1 and B1, piericidin B1 N-oxide inhibited ATP synthesis in A431 cells; however, the effect of piericidin B1 N-oxide on PI synthesis was stronger than that of piericidins A1 and B1. At the concentration inhibiting PI synthesis, piericidin B1 N-oxide showed no inhibitory effect on DNA, RNA, or protein synthesis. We also demonstrated that piericidin B1 N-oxide reversibly inhibited the growth of A431 cells in situ and suppressed the growth of Ehrlich carcinoma in vivo when administered to mice by intraperitoneal (ip) injection.

• Authors: H Nishioka, M Imoto, T Imaoka, T Sawa, T Takeuchi, K Umezawa
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 47 Issue 4 Pg. 447-52 (Apr 1994) ISSN: 0021-8820 [Print] England
• PMID: 8195045 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Cyclic N-Oxides
• DNA, Neoplasm
• Neoplasm Proteins
• Phosphatidic Acids
• Phosphatidylinositols
• Pyridines
• RNA, Neoplasm
• piericidin B1 N-oxide
• Epidermal Growth Factor
• Adenosine Triphosphate

Topics

• Adenosine Triphosphate (biosynthesis)
• Animals
• Antibiotics, Antineoplastic (pharmacology, toxicity)
• Carcinoma, Ehrlich Tumor (drug therapy, pathology)
• Cell Division (drug effects)
• Cyclic N-Oxides (pharmacology, toxicity)
• DNA, Neoplasm (biosynthesis)
• Epidermal Growth Factor (pharmacology)
• Humans
• Mice
• Neoplasm Proteins (biosynthesis)
• Phosphatidic Acids (metabolism)
• Phosphatidylinositols (biosynthesis)
• Pyridines (pharmacology, toxicity)
• RNA, Neoplasm (biosynthesis)
• Streptomyces (metabolism)
• Tumor Cells, Cultured