[Quantitative immunohistochemical study of ras oncogene product P21 in laryngeal carcinomas and its clinical importance].

Thirty cases of laryngeal carcinoma and 6 cases of vocal polyps and normal laryngeal epithelium were studied by immunohistochemical methods. The results showed that P21 content in laryngeal carcinoma increased markedly than that in normal laryngeal epithelium and vocal polyps (P < 0.01). It suggests that laryngeal carcinoma is correlated with the activation of ras oncogene. There was no significant correlation between P21 contents and pathological classification of laryngeal carcinoma, but increase in contents was correlated with metastasis and recurrence.
AuthorsZ S Liu
JournalZhonghua er bi yan hou ke za zhi (Zhonghua Er Bi Yan Hou Ke Za Zhi) Vol. 28 Issue 5 Pg. 295-6, 315 ( 1993) ISSN: 0412-3948 [Print] CHINA
PMID8192934 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)
  • Adult
  • Aged
  • Carcinoma, Squamous Cell (chemistry, pathology)
  • Female
  • Humans
  • Immunohistochemistry
  • Laryngeal Neoplasms (chemistry, pathology)
  • Male
  • Middle Aged
  • Prognosis
  • Proto-Oncogene Proteins p21(ras) (analysis)

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