Abstract | PURPOSE: METHODS: RESULTS: Three of the patients treated with silk hemorrhaged after embolization, and two of these patients died. Neuropathologic analysis of four patients showed acute perivascular inflammation, sometimes quite severe. CONCLUSIONS: The inflammatory response to silk may explain its effectiveness in producing vascular occlusion. However, a fulminate vasculitis theoretically can predispose to delayed hemorrhage. Other problems with silk include the pressure required to inject the agent and the inability to determine the final site of deposition of the silk. Although other embolic agents may share some of these potential difficulties, we feel that the disadvantages outweigh the advantages of silk as an embolic agent.
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Authors | J P Deveikis, H J Manz, A J Luessenhop, A J Caputy, A I Kobrine, D Schellinger, N Patronas |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 15
Issue 2
Pg. 263-71
(Feb 1994)
ISSN: 0195-6108 [Print] United States |
PMID | 8192071
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Insect Proteins
- Proteins
- Silk
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Topics |
- Adult
- Cerebral Angiography
- Cerebral Arteries
(pathology)
- Cerebral Hemorrhage
(diagnostic imaging, pathology, surgery)
- Combined Modality Therapy
- Craniotomy
- Embolization, Therapeutic
(methods)
- Female
- Humans
- Insect Proteins
- Intracranial Arteriovenous Malformations
(diagnostic imaging, pathology, surgery)
- Male
- Middle Aged
- Postoperative Complications
(diagnostic imaging)
- Preoperative Care
- Proteins
- Silk
- Sutures
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