HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Treatment of tardive dyskinesias with 7-methoxytacrine. I].

Abstract
The 7-metoxytacrine (7-MEOTA) is an original Czech cholinergic agent synthetized in the labs of the Military Medical Academy in Hradec Králové. The treatment of tardive dyskinesias is one of the possible indications of the use of 7-MEOTA in clinical practice. The authors have summed up their experience from the first phase of clinical tests with 7-MEOTA in psychiatrical patients suffering from tardive dyskinesias in long-termed administration of cholinergic agents. The clinical efficiency and tolerance of 7-MEOTA have been evaluated after a single administration of 100 mg of 7-MEOTA per os in 19 patients. A reduction of dyskinesias was observed as early as 4 h following the testing dose. In 5 patients, viz. in 26% a reduction of dyskinesias was observed of more than 50% of the original value of the total score of the testing scale AIMS. Except for a slight decrease of the blood pressure and a mild somnolence in 3 patients no other undesirable effects have been observed. In some patients a slight euphorization effect of 7-MEOTA has been found.
AuthorsH Hanus, I Tůma, J Fusek, J Patocka
JournalSbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum (Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl) Vol. 36 Issue 1-2 Pg. 37-45 ( 1993) ISSN: 0049-5522 [Print] Czech Republic
Vernacular TitleLécba tardivních dyskinéz 7-metoxytakrinem--I.
PMID8191251 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Tacrine
  • 7-methoxytacrine
Topics
  • Adult
  • Dyskinesia, Drug-Induced (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Tacrine (analogs & derivatives, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: