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Infection of human endothelial cells by Rickettsia rickettsii causes a significant reduction in the levels of key enzymes involved in protection against oxidative injury.

Abstract
The activities of glucose-6-phosphate dehydrogenase, catalase, and glutathione peroxidase were significantly decreased in human endothelial cells infected with the obligate intracellular bacterium Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever. This observation lends additional support to our hypothesis implicating oxidative damage in endothelial cell injury caused by this microorganism.
AuthorsP S Devamanoharan, L A Santucci, J E Hong, X Tian, D J Silverman
JournalInfection and immunity (Infect Immun) Vol. 62 Issue 6 Pg. 2619-21 (Jun 1994) ISSN: 0019-9567 [Print] United States
PMID8188386 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Oxidants
  • Glucosephosphate Dehydrogenase
  • Catalase
  • Glutathione Peroxidase
Topics
  • Catalase (metabolism)
  • Cells, Cultured
  • Endothelium, Vascular (enzymology, microbiology)
  • Glucosephosphate Dehydrogenase (metabolism)
  • Glutathione Peroxidase (metabolism)
  • Humans
  • Oxidants (toxicity)
  • Rickettsia rickettsii (pathogenicity)

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