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[Reversible myelofibrosis in angioimmunoblastic lymphadenopathy].

Abstract
Ankle oedema and abdominal swelling suddenly developed in a 55-year-old woman who also had lymphadenopathy in the neck, axillae and groin. Ultrasonography demonstrated hepatosplenomegaly, ascites and pleural effusions. Histological examination of some lymph-nodes from the axilla and groin revealed angioimmunoblastic lymphadenopathy (low-malignant peripheral T cell lymphoma). Bone-marrow biopsy was undertaken because of a normocytic anaemia (haemoglobin 4.9 g/dl) requiring blood transfusion, thrombocytopenia (5000/microliters) and monoclonal IgG gammopathy. This showed lymphoma-associated secondary myelofibrosis. Treatment with prednisone (2 mg/kg daily for 8 weeks) and vincristine (1 mg/m2 once weekly for 4 weeks) brought about partial remission of the angioimmunoblastic lymphadenopathy with normalization of the clinical and laboratory findings, the splenohepatomegaly regressed, and there was only a small amount of ascites. Four months after onset of the illness bone-marrow biopsy also showed regression of the myelofibrosis.
AuthorsT Orth, U Treichel, W J Mayet, S Störkel, K H Meyer zum Büschenfelde
JournalDeutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 119 Issue 19 Pg. 694-8 (May 13 1994) ISSN: 0012-0472 [Print] Germany
Vernacular TitleReversible myelofibrose bei angioimmunoblastischer Lymphadenopathie.
PMID8187622 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Vincristine
  • Prednisone
Topics
  • Biopsy, Needle
  • Bone Marrow (pathology)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunoblastic Lymphadenopathy (diagnosis, drug therapy, etiology, pathology)
  • Lymph Nodes (pathology)
  • Lymphoma, Non-Hodgkin (complications, diagnosis, drug therapy, pathology)
  • Middle Aged
  • Prednisone (administration & dosage)
  • Primary Myelofibrosis (diagnosis, drug therapy, etiology, pathology)
  • Remission Induction
  • Vincristine (administration & dosage)

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