Changes of myocardial myoglobin, myosin and creatine kinase in cases of sudden nocturnal death syndrome.

Abstract

Myoglobin, myosin creatine kinase MM (CK-MM), creatine kinase BB(CK-BB) in cardiac muscle and H chain of myosin in atrial and ventricular muscle were studied in specimens from 8 patients who died of sudden nocturnal death syndrome (SNDS) by avidin-biotin complex (ABC) method to investigate the possible early or very early myocardial ischemia in the syndrome. Hematoxylin-eosin staining was conducted for comparison. The results showed evident loss of CK-MM, CK-BB, myoglobin and myosin from cardiac muscle cells, indicating that occurrence of SNDS is closely associated with acute myocardial ischemia.

• Authors: B L Zhu, D W Guan, D X Li, O Tohru, N Taizo
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 107 Issue 1 Pg. 36-40 (Jan 1994) ISSN: 0366-6999 [Print] China
• PMID: 8187570 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• Myoglobin
• Creatine Kinase
• Myosins

Topics

• Adult
• Creatine Kinase (metabolism)
• Death, Sudden, Cardiac (etiology)
• Humans
• Immunoenzyme Techniques
• Isoenzymes
• Male
• Middle Aged
• Myocardial Ischemia (complications, metabolism)
• Myocardium (metabolism)
• Myoglobin (metabolism)
• Myosins (metabolism)
• Syndrome