Lack of response to corticosteroids and pulse cyclophosphamide therapy in Cogan's syndrome.

Abstract

A 17-year-old girl with Cogan's syndrome is described. Total and irreversible hearing loss occurred which was unresponsive to corticosteroids and immunosuppressive therapy. The girl died a year later from subarachnoid haemorrhage. The lethal prognosis in Cogan's syndrome despite the available treatment is emphasized.

• Authors: G Vaiopoulos, P P Sfikakis, B Skoumas, E Kavouklis, E Doukas, P Kaklamanis
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 13 Issue 1 Pg. 110-2 (Mar 1994) ISSN: 0770-3198 [Print] Germany
• PMID: 8187429 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Cyclophosphamide

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Fatal Outcome
• Female
• Hearing Loss, Sensorineural (drug therapy)
• Humans
• Keratitis (drug therapy)
• Syndrome
• Vasculitis (drug therapy)
• Vestibular Diseases (drug therapy)