[The predictive parameters in the response to almitrine treatment].

Abstract

Almitrine bimesylate (AB) improves hypoxemia in an undetermined number of patients with respiratory failure. Our objective was to try to identify the patients likely to benefit from this treatment. We undertook a double blind study of AB (50-100 mg/day) vs placebo in 21 randomly chosen patients diagnosed as having chronic obstructive bronchitis who were receiving oxygen therapy in the home. The study lasted 3 months (T0 to T3). PaO2 rose from 51 +/- 5.3 to 58.5 +/- 10 mmHg (6.8 +/- 0.7 to 7.8 +/- 1.3 Kpa) in the 12 patients taking AB (p < 0.05). The remaining gasometric variables and results of functional respiratory exploration were unchanged. The 7 patients receiving AB who were defined as responding-whose PaO2 rose more than 5 mmHg (0.66 Kpa)-presented T0 values lower than those of the 7 non-responding patients in the same group, with respect to CO2 occlusion pressure, mean inspiratory flow and minute ventilation for both air and CO2. These variables can serve as predictors for gasometric response to AB.

• Authors: J M González Ruiz, J Villamor, J M Pino, J Muñoz, S D Lobato, C Prados
• Journal: Archivos de bronconeumologia (Arch Bronconeumol) Vol. 30 Issue 3 Pg. 141-4 (Mar 1994) ISSN: 0300-2896 [Print] Spain
• Vernacular Title: Parámetros predictivos en la respuesta al tratamiento con almitrina.
• PMID: 8186906 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Almitrine

Topics

• Aged
• Almitrine (therapeutic use)
• Analysis of Variance
• Bronchitis (drug therapy, epidemiology, physiopathology)
• Double-Blind Method
• Humans
• Lung Diseases, Obstructive (drug therapy, epidemiology, physiopathology)
• Male
• Middle Aged
• Prognosis
• Respiratory Function Tests (statistics & numerical data)
• Respiratory Insufficiency (drug therapy, epidemiology, physiopathology)