Anti-tumor effect of tumor necrosis factor combined with electrotherapy on mouse sarcoma.

Abstract

Anti-tumor effectiveness of tumor necrosis factor (TNF)-alpha applied peritumorally was assessed in combination with local electrotherapy on subcutaneous SA-1 tumors in mice. TNF and electrotherapy each induced significant tumor growth delay. In combined treatment using TNF and electrotherapy, a synergistic anti-tumor effect was observed, regardless of whether TNF was injected before or after electrotherapy. An extra anti-tumor effect was achieved when TNF in the same total dose (2 x 10(5) U) was split into a priming dose (0.5 x 10(5) U) 1 h before electrotherapy and the other (1.5 x 10(5) U) 24 h thereafter. As the result of this therapeutic combination survival rate of the animals was 40%. No animal survived more than 50 days in groups subjected to TNF or electrotherapy treatment alone. Combined treatment with TNF and electrotherapy induced massive tumor destruction, confirmed by histological examination 2 days after the treatment. The results indicate that TNF and electrotherapy interact and that they can be effective in control of local tumor growth.

• Authors: G Sersa, R Golouh, D Miklavcic
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 5 Issue 1 Pg. 69-74 (Feb 1994) ISSN: 0959-4973 [Print] England
• PMID: 8186433 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Electric Stimulation Therapy
• Mice
• Mice, Inbred A
• Neoplasm Transplantation
• Sarcoma, Experimental (drug therapy, pathology, therapy)
• Skin Neoplasms (drug therapy, pathology, therapy)
• Time Factors
• Tumor Necrosis Factor-alpha (administration & dosage, therapeutic use)