Cellular accumulation and DNA damage induced by liposomal cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum+ ++(II) in LoVo and LoVo/PDD cells.

Abstract	Liposomal cis-bis-neodecanato-trans-R,R-1,2-diaminocyclohexaneplatinum (11) (L-NDDP) is a liposome-entrapped platinum complex that has shown partial lack of cross-resistance with cisplatin in human colon carcinoma LoVo cells. We studied the drug accumulation and DNA damage induced by L-NDDP and cisplatin in LoVo and LoVo/PDD cells. Our results indicate that the accumulation of L-NDDP in LoVo cells is several-fold higher than that of cisplatin; that the accumulation of L-NDDP is similar in both cell lines, whereas that of cisplatin is reduced by 2- to 3-fold in LoVo/PDD cells; and that the transmembrane transport of cisplatin is highly dependent on temperature while that of L-NDDP is not. We also found that the cytotoxicity of both agents correlates with the extent of DNA-protein cross-link formation, and that DNA interstrand cross-linking does not appear to play a role in the cytotoxicity of L-NDDP, whereas it correlates with cisplatin cytotoxicity.
Authors	I Han, T Nguyen, L Y Yang, A R Khokhar, R Perez-Soler
Journal	Anti-cancer drugs (Anticancer Drugs) Vol. 5 Issue 1 Pg. 64-8 (Feb 1994) ISSN: 0959-4973 [Print] England
PMID	8186432 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antineoplastic Agents Cross-Linking Reagents DNA, Neoplasm Drug Carriers Liposomes Neoplasm Proteins Organoplatinum Compounds bis-neodecanoato-1,2-diaminocyclohexaneplatinum(II) Cisplatin
Topics	Antineoplastic Agents (pharmacokinetics, therapeutic use) Carcinoma (drug therapy, metabolism) Cell Survival (drug effects) Cisplatin (pharmacokinetics, pharmacology) Colonic Neoplasms (drug therapy, metabolism) Cross-Linking Reagents (pharmacology) DNA Damage DNA, Neoplasm (drug effects, metabolism) Drug Carriers Humans Liposomes Neoplasm Proteins (drug effects, metabolism) Organoplatinum Compounds (pharmacokinetics, therapeutic use) Temperature Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!