[A comparative clinical study on the treatment of head and neck tumors by adjuvant chemotherapy with HCFU--Second Study by Kinki Head and Neck Tumor Study Group].

Abstract

In the first study by the "Kinki Head and Neck Tumor Study Group," we performed a comparative study to investigate intergroup difference between a control group consisting of patients given radical treatment only, and a HCFU group consisting of patients receiving long-term administration of HCFU after radical treatment. We earlier reported that subsequent observations by stratification revealed a favorable tendency in the cumulative disease-free rate in Stage II and Stage III patients in the HCFU group. In the second study, the same methods of treatment as in the first study were compared in a prospective control study. No differences were found between the two groups in Stage II patients. In Stage III patients, however, the disease-free rate tended to increase significantly in the HCFU group as in the first study.

• Authors: K Yoshino, T Sato, Y Nakai, M Tanabe, T Matsunaga, T Kozuka, S Sakai, M Miyaguchi, T Nishimura, H Matsuoka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 21 Issue 6 Pg. 777-83 (May 1994) ISSN: 0385-0684 [Print] Japan
• PMID: 8185335 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Antineoplastic Agents
• carmofur
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Agents (administration & dosage)
• Carcinoma, Squamous Cell (drug therapy, mortality, pathology)
• Chemotherapy, Adjuvant
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage, analogs & derivatives)
• Head and Neck Neoplasms (drug therapy, mortality, pathology)
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Prospective Studies
• Survival Rate