Association between HLA-DQB1 alleles and risk for cervical cancer in African-American women.

Abstract	Squamous-cell carcinoma of the cervix and its precursor lesions are associated with human papillomavirus (HPV) infection. Epidemiological studies indicate that HPV infection in itself is not sufficient for cervical-cancer induction, suggesting that other factors contribute to carcinogenesis. We have investigated the potential role of host genetic background as one such factor. We screened a series of squamous-cell carcinomas of the cervix for HLA-class-II DQB1* alleles by the polymerase chain reaction and site-specific oligonucleotide probe hybridization and for HPV type from African-American women using a local, ethnically matched control panel. Statistically significant associations for increase in relative risk for cervical cancer were seen for DQB10303 and DQB10604. DQB10201 and the heterozygote DQB10301/*0501 showed a decrease in relative risk for cervical cancer. HPV typing revealed no association between virus type and DQB1 alleles. Our results confirm other studies showing an increase in relative risk for cervical cancer associated with HLA-DQ3 alleles in Caucasians.
Authors	L Gregoire, W D Lawrence, D Kukuruga, A B Eisenbrey, W D Lancaster
Journal	International journal of cancer (Int J Cancer) Vol. 57 Issue 4 Pg. 504-7 (May 15 1994) ISSN: 0020-7136 [Print] United States
PMID	8181853 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	HLA-DQ Antigens HLA-DQ beta-Chains HLA-DQB1 antigen Oligonucleotide Probes
Topics	Adult Aged Aged, 80 and over Alleles Base Sequence Black People (genetics) Carcinoma, Squamous Cell (genetics, immunology) Female HLA-DQ Antigens (genetics) HLA-DQ beta-Chains Humans Middle Aged Molecular Sequence Data Nucleic Acid Hybridization Oligonucleotide Probes Papillomaviridae Polymerase Chain Reaction Reference Values Risk Factors Uterine Cervical Neoplasms (genetics, immunology, microbiology) White People

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!