Boron neutron capture therapy (BNCT): a radiation oncology perspective.

Abstract

Boron neutron capture therapy (BNCT) offers considerable promise in the search for the ideal cancer therapy, a therapy which selectively and maximally damages malignant cells while sparing normal tissue. This bimodal treatment modality selectively concentrates a boron compound in malignant cells, and then "activates" this compound with slow neutrons resulting in a highly lethal event within the cancer cell. This article will review this treatment modality from a radiation oncology, biology, and physics perspective. The remainder of the articles in this special issue of the Journal will provide a survey of the current "state-of-the-art" in this rapidly expanding field, including information with regard to boron compounds and their localization.

• Authors: R V Dorn 3rd
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 28 Issue 5 Pg. 1189-201 (Mar 30 1994) ISSN: 0360-3016 [Print] United States
• PMID: 8175405 (Publication Type: Journal Article, Review)

Topics

• Boron Neutron Capture Therapy (adverse effects)
• Humans
• Neoplasms (radiotherapy)