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Synthesis, characterization, and analytical studies of adosupine, a potential new drug for urinary incontinence.

Abstract
The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and identified as the hydrolysis product of the lactam ring present in the adosupine structure.
AuthorsA Perico, A Triolo, G Viti, C Mannucci, G Caviglioli, A Cocchini, V Pestellini, P Paoli, P Dapporto
JournalJournal of pharmaceutical sciences (J Pharm Sci) Vol. 83 Issue 2 Pg. 137-42 (Feb 1994) ISSN: 0022-3549 [Print] United States
PMID8169779 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dibenzazepines
  • adosupine
Topics
  • Chromatography, High Pressure Liquid
  • Crystallography, X-Ray
  • Dibenzazepines (analysis, chemical synthesis, chemistry)
  • Drug Stability
  • Hydrolysis
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Conformation
  • Urinary Incontinence (drug therapy)

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