Effect of immunomodulation on experimental hymenolepiasis nana in mice.

Abstract

Oral infection of cortisone treated and diabetes induced groups of mice (immunosuppressed) with H. nana eggs, whether before or after infection, showed persistent hyperinfection of the gut with H. nana worms and cysticercoids, dissemination of cysticercoids to the liver and marked degenerative changes in the intestinal mucosa and liver. BCG treated groups (immunostimulated) whether before or after infection, showed no significant changes compared to the control group. Subcutaneous infection of mice resulted in severe localized cellular reaction around and infiltrating the injected H. nana eggs in BCG treated and control groups. BCG did not inhibit larval development, as cysticercoids were found in the injected sites. In cortisone treated and diabetic groups, mild cellular reaction was observed.

• Authors: M K Makled, N H Mohamed, S A Soffar, N M Sabry, A A el Kadery, N M Otifa
• Journal: Journal of the Egyptian Society of Parasitology (J Egypt Soc Parasitol) Vol. 24 Issue 1 Pg. 211-22 (Apr 1994) ISSN: 1110-0583 [Print] Egypt
• PMID: 8169445 (Publication Type: Journal Article)

Chemical References

• Cortisone

Topics

• Animals
• Cortisone
• Diabetes Mellitus, Experimental (complications, immunology)
• Hymenolepiasis (complications, immunology)
• Immunocompromised Host
• Immunosuppression Therapy
• Mice
• Mycobacterium bovis
• Specific Pathogen-Free Organisms