An experimental study of cefixime in the treatment of Streptococcus pneumoniae otitis media.

Abstract	Previous studies using the chinchilla animal model demonstrated that the third generation cephalosporin cefixime (Suprax) with split dosing was as effective as ampicillin in sterilizing the middle ear cleft when infected with S. pneumoniae. In this investigator-blinded, randomized trial, a single daily dose of cefixime (8 mg/kg per day) performed as well as split dosing of cefixime (8 mg/kg every 8 h) and ampicillin (150 mg/kg every 8 h) in the time to sterilization of the middle ear cleft. No statistically significant differences were noted between groups in otoscopy or tympanometry. All antibiotic regimens performed better than saline control (P < 0.0001) with regard to time to sterilization of the middle ear cleft. The results of this study support the daily administration of cefixime as an effective agent for the treatment of otitis media due to its extended half-life and broad antibiotic spectrum.
Authors	A E Magit, J N Dolitsky, W J Doyle, J D Swarts, J T Seroky, R M Rosenfeld
Journal	International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 29 Issue 1 Pg. 1-9 (Mar 1994) ISSN: 0165-5876 [Print] Ireland
PMID	8169042 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anti-Infective Agents Placebos Ampicillin Cefixime Cefotaxime
Topics	Acoustic Impedance Tests Acute Disease Ampicillin (administration & dosage, therapeutic use) Animals Anti-Infective Agents (administration & dosage, blood, pharmacokinetics, therapeutic use) Cefixime Cefotaxime (administration & dosage, analogs & derivatives, blood, pharmacokinetics, therapeutic use) Chinchilla Ear, Middle (microbiology, pathology) Endoscopy Injections, Intramuscular Otitis Media (drug therapy, metabolism, microbiology, pathology) Placebos Pneumococcal Infections (drug therapy) Single-Blind Method Time Factors

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