Abstract | BACKGROUND: METHODS: The response of PTHi to treatment over 6 months with ivVD was evaluated in 18 patients with moderate-severe HPT resistant to the classical schedules. RESULTS: An important decrease was observed in the PTHi values (basal: 698 +/- 277 pg/ml, end of treatment: 272 +/- 200; p < 0.05). Alkaline phosphatase values followed a parallel course (basal: 476 +/- 286 U/l, end of treatment: 301 +/- 276 U/l, p < 0.05). Fifty-five percent of the patients presented hypercalcemia at some time (Ca > or = 11.5 mg/dl) being controlled by a decrease in the doses of calcitriol or calcium in dialysis fluid. No response was observed in 3 patients (17%) with treatment being discontinued due to presentation of uncontrollable hypercalcemia. CONCLUSIONS: The administration of intravenous calcitriol at high and intermittent doses is effective in a considerable number of patients with hyperparathyroidism resistant to the classical oral schedules. Its use may avoid surgical parathyroidectomy in some cases.
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Authors | J Almirall, V Torregrosa, P Arrizabalaga, A Cases, J Oliva |
Journal | Medicina clinica
(Med Clin (Barc))
Vol. 102
Issue 9
Pg. 325-8
(Mar 12 1994)
ISSN: 0025-7753 [Print] Spain |
Vernacular Title | El calcitriol por vía intravenosa en el tratamiento del hiperparatiroidismo secundario refractario de la insuficiencia renal crónica terminal. |
PMID | 8164458
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Calcitriol
(administration & dosage)
- Drug Evaluation
- Female
- Humans
- Hyperparathyroidism
(epidemiology)
- Hyperparathyroidism, Secondary
(blood, drug therapy, etiology)
- Infusions, Intravenous
- Kidney Failure, Chronic
(blood, complications, epidemiology, therapy)
- Male
- Middle Aged
- Parathyroid Glands
(drug effects, physiopathology)
- Prospective Studies
- Time Factors
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