[Transport of 2,5-dimethoxy-4-methylamphetamine by macroheterocycles across erythrocyte membranes].

Abstract

Transport of 2,5-dimethoxy-4-methylamphetamine across human erythrocytes by the 18-crown-6, monoaza-15-crown-5 and diaza-18-crown-6 is studied and evaluated spectrophotometrically. It is shown that crown-ethers at low concentration (1-2 mM) protect erythrocytes against their natural homolysis. 2,5-dimethoxy-4-methylamphetamine provides 2-5% hemolysis of erythrocytes. In the presence of macrocycles (5 mM) hemolysis of erythrocytes increases from 6.5 to 30%. A hemolytic effect of 2,5-dimethoxy-4-methylamphetamine depends on the structure of the crown ethers and, apparently, confirms significant role of complexes of the crown-ethers with amine in these processes.

• Authors: T L Karaseva, A S Iavorskiĭ, V I Pavlovskiĭ, Zh N Tsapenko
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1993 Sep-Oct Vol. 65 Issue 5 Pg. 95-8 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Transport 2,5-dimetoksi-4-metilamfetamina makrogeterotsiklami cherez membrany éritrotsitov.
• PMID: 8160305 (Publication Type: English Abstract, Journal Article)

Chemical References

• Heterocyclic Compounds
• 2,5-Dimethoxy-4-Methylamphetamine

Topics

• 2,5-Dimethoxy-4-Methylamphetamine (pharmacokinetics)
• Biological Transport (physiology)
• Erythrocyte Membrane (metabolism)
• Heterocyclic Compounds (metabolism)
• Humans