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Inhibition of endopeptidase EC 3.4.24.11 by candoxatril lowered blood pressure and increased urinary but not plasma atrial natriuretic peptide in essential hypertension.

AuthorsT J Tunny, M D Ziesak, R Armstrong, S A Klemm, M Stowasser, W L Finn, R D Gordon
JournalJournal of hypertension. Supplement : official journal of the International Society of Hypertension (J Hypertens Suppl) Vol. 11 Issue 5 Pg. S222-3 (Dec 1993) ISSN: 0952-1178 [Print] England
PMID8158355 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antihypertensive Agents
  • Indans
  • Propionates
  • Atrial Natriuretic Factor
  • candoxatril
  • Neprilysin
Topics
  • Adult
  • Aged
  • Antihypertensive Agents (therapeutic use)
  • Atrial Natriuretic Factor (blood, urine)
  • Blood Pressure (drug effects)
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Indans (therapeutic use)
  • Male
  • Middle Aged
  • Neprilysin (antagonists & inhibitors)
  • Propionates (therapeutic use)

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