Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea.

Abstract

Tingenone[1],20-hydroxy-20-epi-tingenone[2],celastrol[ 3], and salaspermic acid [4] have been isolated from Kokoona ochracea stem bark. The quinone-methide triterpenes 1-3 exhibited strong but non-specific in vitro cytotoxicity against P-388 murine lymphocytic leukemia cells and a panel of human cancer cell lines. Salaspermic acid [4] was not active in all the cancer cell lines used in this investigation. 13C-nmr spectra assignments for salaspermic acid have been accomplished through the application of 1D and 2D nmr spectral techniques, and 13C-nmr assignments for celastrol [3] have been revised.

• Authors: O Ngassapa, D D Soejarto, J M Pezzuto, N R Farnsworth
• Journal: Journal of natural products (J Nat Prod) Vol. 57 Issue 1 Pg. 1-8 (Jan 1994) ISSN: 0163-3864 [Print] United States
• PMID: 8158155 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Triterpenes
• salaspermic acid

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Leukemia P388 (drug therapy)
• Magnetic Resonance Spectroscopy
• Mice
• Philippines
• Plants, Medicinal (chemistry)
• Triterpenes (isolation & purification, pharmacology)
• Tumor Cells, Cultured