BW-A522 blocks adenosine A3 receptor-mediated hypotensive responses in the rat.

Abstract

The effects of 3-(3-iodo-4-aminobenzyl)-8-(4-oxyacetate)-1-propylxanthine (I-ABOPX; BW-A522), which has nanomolar affinity for the recently cloned human and sheep adenosine A3 receptor, on the putative A3 receptor mediated hypotensive response to N6-2-(4-aminophenyl)ethyl adenosine (APNEA) in the rat have been investigated. Following blockade of A1 and A2 receptors with 8-(p-sulphophenyl)theophylline, BW-A522, 10 and 40 mg/kg i.v., blocked dose-dependently and surmountable the hypotensive response to APNEA. The results provide direct evidence of an A3 receptor in the cardiovascular system of the rat which induces hypotension when activated.

• Authors: J R Fozard, J P Hannon
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 252 Issue 2 Pg. R5-6 (Feb 03 1994) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8157050 (Publication Type: Journal Article)

Chemical References

• N(6)-2-(4-aminophenyl)ethyladenosine
• Purinergic P1 Receptor Antagonists
• Xanthines
• BW A522
• 8-(4-sulfophenyl)theophylline
• Theophylline
• Adenosine

Topics

• Adenosine (analogs & derivatives, antagonists & inhibitors, pharmacology)
• Animals
• Blood Pressure (drug effects)
• Depression, Chemical
• Dose-Response Relationship, Drug
• Male
• Purinergic P1 Receptor Antagonists
• Rats
• Rats, Sprague-Dawley
• Theophylline (analogs & derivatives, pharmacology)
• Xanthines (pharmacology)