[Long-term treatment of sleep apnea with evening administration of oral retard theophylline].

Abstract

In 776 patients suffering from sleep apnoea long-term treatment with sustained-release theophylline was investigated. Responders show a significant reduction of apnoea phases. Using an individual theophylline dosage with morning theophylline concentrations between 5 and 8 micrograms/ml, only few side effects occurred. Positive effects on cardiopulmonary capacity were seen.

• Authors: P Dorow, S Thalhofer, S Heinemann, P Meissner, U Kühler
• Journal: Pneumologie (Stuttgart, Germany) (Pneumologie) Vol. 47 Suppl 4 Pg. 778-9 (Dec 1993) ISSN: 0934-8387 [Print] Germany
• Vernacular Title: Langzeitbehandlung der Schlafapnoe mit einer abendlichen Gabe von oralem retardierten Theophyllin.
• PMID: 8153109 (Publication Type: English Abstract, Journal Article)

Chemical References

• Theophylline

Topics

• Administration, Oral
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Follow-Up Studies
• Humans
• Long-Term Care
• Polysomnography (drug effects)
• Sleep Apnea Syndromes (drug therapy, physiopathology)
• Theophylline (administration & dosage, adverse effects)