Increase in c-erbA alpha 2 mRNA in the parvocellular region of the paraventricular nucleus of the hypothalamus following thyroidectomy in the adult male rat.

Abstract

To examine thyroid hormone regulation of c-erbA alpha 2 mRNA expression in the parvo-cellular region of the paraventricular nucleus of the rat hypothalamus (pPVN), quantitative in situ hybridization was performed using 3H-labeled probe complementary to c-erbA alpha 2 mRNA. Thyroidectomy induced a significant increase in the number of silver grains overlying the cytoplasm in the pPVN relative to sham-operated controls. This effect was prevented by daily injection of thyroxine. These results indicate that hypothyroidism induced an increase in cellular c-erbA alpha 2 mRNA level in the pPVN.

• Authors: N Koibuchi, R B Gibbs, K E Jones, S Yamaoka, W W Chin, D W Pfaff, M Suzuki
• Journal: Neuroscience letters (Neurosci Lett) Vol. 164 Issue 1-2 Pg. 159-62 (Dec 24 1993) ISSN: 0304-3940 [Print] Ireland
• PMID: 8152593 (Publication Type: Journal Article)

Chemical References

• RNA, Messenger
• Triiodothyronine
• Thyrotropin
• Thyroxine

Topics

• Animals
• In Situ Hybridization
• Male
• Oncogenes (physiology)
• Paraventricular Hypothalamic Nucleus (metabolism)
• RNA, Messenger (biosynthesis)
• Rats
• Rats, Sprague-Dawley
• Silver Staining
• Thyroidectomy
• Thyrotropin (blood)
• Thyroxine (metabolism)
• Triiodothyronine (metabolism)