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Fatal methemoglobinemia due to inhalation of isobutyl nitrite.

Abstract
Isobutyl nitrite is a popular recreational drug among both homosexuals and heterosexuals as it is alleged to enhance sexual pleasure and prolong orgasm. In contrast to the ingestion of this volatile nitrite, inhalation is associated only rarely with serious sequelae, though symptomatic methemoglobinemia may occur. The case reported is the first documented fatality from inhalation of isobutyl nitrite. The widespread use of isobutyl nitrite is a cause for concern and physicians should be aware of the potentially fatal consequence of abuse, particularly in those with ischemic heart disease, and its management.
AuthorsS M Bradberry, R M Whittington, D A Parry, J A Vale
JournalJournal of toxicology. Clinical toxicology (J Toxicol Clin Toxicol) Vol. 32 Issue 2 Pg. 179-84 ( 1994) ISSN: 0731-3810 [Print] United States
PMID8145358 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Nitrites
  • isobutyl nitrite
Topics
  • Administration, Inhalation
  • Aged
  • Fatal Outcome
  • Humans
  • Hypoxia (chemically induced)
  • Male
  • Methemoglobinemia (chemically induced)
  • Nitrites (administration & dosage, poisoning)
  • Substance-Related Disorders

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