Abstract | OBJECTIVE: METHODS: Action potentials were recorded with the standard glass microelectrode technique in right ventricular preparations excised from rat hearts and superfused under baseline conditions and with drug containing or peptide containing Tyrode solution. Ventricular hypertrophy was induced in response to hypertension (unilaterally nephrectomised, DOCA- salt model) or 4 week old left ventricular infarction. RESULTS: In preparations from normal rat hearts, captopril increased action potential duration in a concentration dependent fashion [EC50 = 3.5 x 10(-8) M; maximum effect = 44(SEM 5.1)% prolongation at 10(-5) M for action potential duration at 90% repolarisation, APD90]. Perindoprilat similarly caused a dose dependent increase in action potential duration, but with 100 times greater potency [EC50 = 3.1 x 10(-10) M; maximum effect = 71(11)% prolongation at 10(-5) M for APD90]. SQ 14,534, a stereoisomer of captopril with one hundredth the ACE inhibitor potency, had no significant effect on action potential duration at 10(-5) M. Angiotensin I and bradykinin caused concentration dependent prolongation of action potential, but angiotensin II (10(-6) M) had no effect. Captopril (10(-5) M) had no significant effect in the hypertrophied right ventricle from DOCA- salt hypertensive rats, but significantly increased APD90 [39(4.9)%] in right ventricular preparations from rats with 4 week old anterior left ventricular infarction. CONCLUSIONS:
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Authors | C Ribuot, R Cardinal, L Gouin, P Moreau, D Godin, M Vermeulen, J de Champlain, L Rochette, R Nadeau |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 28
Issue 2
Pg. 221-7
(Feb 1994)
ISSN: 0008-6363 [Print] England |
PMID | 8143304
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Indoles
- perindoprilat
- Angiotensin I
- Captopril
- Bradykinin
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Topics |
- Action Potentials
(drug effects)
- Angiotensin I
(pharmacology)
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Bradykinin
(pharmacology)
- Captopril
(analogs & derivatives, pharmacology)
- Cardiomegaly
(physiopathology)
- Dose-Response Relationship, Drug
- Heart
(physiopathology)
- Hypertension
(physiopathology)
- Indoles
(pharmacology)
- Myocardial Infarction
(physiopathology)
- Rats
- Rats, Sprague-Dawley
- Rats, Wistar
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