Abstract | OBJECTIVE: METHODS: RESULTS: Left ventricular developed pressure decreased significantly in group 3 during ischemia followed by reperfusion (58 +/- 3.1 mmHg versus 42 +/- 2.4 mmHg, P = 0.004), but did not change significantly in any of the other groups. Necrosis score on pathology was highest in group 3; this score also was higher than that in group 5 with free radical scavengers added (3.0 +/- 0.3 versus 2.0 +/- 0.4, P = 0.07) and higher than that of group 2 with reperfusion with buffer only (3.0 +/- 0.3 versus 1.4 +/- 0.5, P < 0.05). Collagen content decreased significantly compared with control in group 3 only with ischemia followed by reperfusion with the addition of oxygen free radicals (18.4 +/- 1.5 versus 11.9 +/- 1.7 g/mg protein, P < 0.05). The addition of free radical scavengers in group 5 mainly attenuated the collagen loss. Scanning electron microscopy revealed profound structural changes of the extracellular collagen matrix in numerous regions of 'stunning' independent of tissue necrosis. CONCLUSIONS:
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Authors | E Lonn, S M Factor, K H Van Hoeven, W H Wen, M Zhao, F Dawood, P Liu |
Journal | The Canadian journal of cardiology
(Can J Cardiol)
Vol. 10
Issue 2
Pg. 203-13
(Mar 1994)
ISSN: 0828-282X [Print] England |
PMID | 8143221
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Free Radical Scavengers
- Free Radicals
- Hypoxanthines
- Reactive Oxygen Species
- Hypoxanthine
- Collagen
- Catalase
- Superoxide Dismutase
- Xanthine Oxidase
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Topics |
- Animals
- Catalase
(pharmacology)
- Collagen
(analysis, drug effects, metabolism)
- Drug Evaluation, Preclinical
- Extracellular Matrix
(drug effects)
- Free Radical Scavengers
- Free Radicals
- Heart
(drug effects)
- Hemodynamics
(drug effects)
- Hypoxanthine
- Hypoxanthines
(pharmacology)
- In Vitro Techniques
- Male
- Microscopy, Electron, Scanning
- Myocardial Reperfusion Injury
(drug therapy, pathology, physiopathology)
- Necrosis
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(pharmacology)
- Severity of Illness Index
- Superoxide Dismutase
(pharmacology)
- Xanthine Oxidase
(pharmacology)
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