[The effect of ethomersol on local cerebral blood flow and edema of the brain tissue in chronic ischemia].

Abstract

The effects of ethomersole (50 mg/kg orally during 10 days) on local cerebral blood flow and cerebral tissue impedance were investigated in rats after left carotid artery ligation and right carotid artery narrowing (blood flow was decreased to 50%). Under these conditions, ethomersole accelerated the blood flow recovery, levelled blood flow asymmetry between the hemispheres, decreased the development of brain edema. In in vitro experiments ethomersole demonstrated a pronounced limitation of cerebral lipid peroxidation.

• Authors: O E Vaizova, T M Plotnikova, M B Plotnikov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 Jan-Feb Vol. 57 Issue 1 Pg. 25-7 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie étomerzola na lokal'nyĭ mozgovoĭ krovotok i otek mozgovoĭ tkani v usloviiakh khronicheskoĭ ishemii.
• PMID: 8142857 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Benzimidazoles
• Vasodilator Agents
• ethomersol

Topics

• Animals
• Benzimidazoles (pharmacology, therapeutic use)
• Brain (drug effects, physiopathology)
• Brain Edema (drug therapy, etiology, physiopathology)
• Brain Ischemia (complications, drug therapy, physiopathology)
• Cerebrovascular Circulation (drug effects)
• Chronic Disease
• Drug Evaluation, Preclinical
• Electric Impedance
• Male
• Rats
• Rats, Wistar
• Time Factors
• Vasodilator Agents (pharmacology, therapeutic use)