LIM domain proteins in leukaemia and development.

Abstract	T cell acute leukaemias involve a number of different classes of oncogenes. A group of such genes is the RBTN family located on chromosomes 11 and 12. Two members of this family, RBTN1/Ttg-1 and RBTN2/Ttg-2, are located near recurring T cell acute lymphocytic leukaemia-associated translocations. Chromosomal translocations to both RBTN1/Ttg-1 and RBTN2/Ttg-2 involve T cell receptor (TCR) genes as result of an erroneous V(D)J joining process. RBTN1/Ttg-1 and RBTN2/Ttg-2 encode related proteins consisting of two cysteine-rich regions called LIM domains. The fact that LIM domains can be found with or without associated homeodomain led to the suggestion that the LIM domains may function as regulators of transcription, and that alterations of transcription networks, after chromosomal translocations, lead to leukaemia. This is a common feature that has been noted in the activation of transcription factors with a variety of structural motifs that include the basic helix-loop-helix motif and the homeodomain in leukaemias.
Authors	I Sánchez-García, T H Rabbitts
Journal	Seminars in cancer biology (Semin Cancer Biol) Vol. 4 Issue 6 Pg. 349-58 (Dec 1993) ISSN: 1044-579X [Print] England
PMID	8142620 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Adaptor Proteins, Signal Transducing DNA-Binding Proteins LIM Domain Proteins LMO1 protein, human LMO2 protein, human Lmo1 protein, mouse Lmo2 protein, mouse Metalloproteins Nuclear Proteins Oncogene Proteins Proto-Oncogene Proteins Transcription Factors DNA Nucleotidyltransferases VDJ Recombinases
Topics	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Cell Transformation, Neoplastic (genetics) Chromosomes, Human, Pair 11 (ultrastructure) Chromosomes, Human, Pair 12 (ultrastructure) DNA Nucleotidyltransferases (genetics) DNA-Binding Proteins (genetics, physiology) Gene Expression Regulation, Leukemic Growth (genetics) Humans Invertebrates (genetics) LIM Domain Proteins Leukemia-Lymphoma, Adult T-Cell (genetics) Metalloproteins (genetics, physiology) Mice Models, Genetic Molecular Sequence Data Multigene Family Nuclear Proteins Oncogene Proteins Protein Structure, Tertiary Proto-Oncogene Proteins Sequence Alignment Sequence Homology, Amino Acid Species Specificity Transcription Factors Translocation, Genetic VDJ Recombinases Zinc Fingers (genetics)

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