Fetal cardiovascular morphology of interrupted aortic arch type B in rats.

Abstract

Interrupted aortic arch type B associated with ventricular septal defect (n = 17) or atrioventricular septal defect (n = 2) was induced in 19 of 300 fetuses by maternal administration of bis-diamine on the 9th and 10th day of pregnancy. After rapid whole-body freezing on the 21st day, the fetuses were studied by means of serial cross-sectional photographs of the frozen thorax. In fetuses with interrupted aortic arch, the ascending aorta was small, and the ratio of its diameter to the diameter of the pulmonary trunk was 0.64 +/- 0.03 (mean +/- SEM) in contrast to 0.96 +/- 0.02 in the control. The aortic arch was interrupted distal to the left common carotid artery (type B of Cerolia and Patton) in all cases.

• Authors: K Momma, M Ando
• Journal: Fetal diagnosis and therapy (Fetal Diagn Ther) 1994 Jan-Feb Vol. 9 Issue 1 Pg. 44-52 ISSN: 1015-3837 [Print] Switzerland
• PMID: 8142052 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diamines
• N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine

Topics

• Abnormalities, Drug-Induced (embryology, pathology)
• Animals
• Aorta, Thoracic (embryology, pathology)
• Aortic Arch Syndromes (chemically induced, embryology, pathology)
• Aortic Valve (embryology, pathology)
• Cardiovascular System (embryology, pathology)
• DiGeorge Syndrome
• Diamines
• Female
• Heart Septal Defects, Atrial (chemically induced, embryology)
• Heart Septal Defects, Ventricular (chemically induced, embryology, pathology)
• Pregnancy
• Rats
• Rats, Wistar