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Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts.

AbstractUNLABELLED:
The effect of inotropics on myocardial ischemia is difficult to predict, since inotropics may influence the determinants of myocardial O2-demand and O2-supply differently. Several phosphodiesterase-inhibitors have been reported to possess antiischemic properties related in vivo to their hemodynamic and O2-sparing effects. The effects of amrinone (CAS 60719-84-8) (10(-6) mol/l or 5 x 10(-5) mol/l) or milrinone (CAS 78415-72-2) 10(-5) mol/l) on myocardial ischemia extent and infarct size were compared in isolated electrically paced rabbit hearts (Langendorff, constant pressure: 70 cm H2O, Tyrode solution, Ca2+ 1.8 mmol/l). Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography. Infarct size was determined by Evan's blue dye and nitroblue-tetrazolium staining and planimetry. At low concentration (10(-6) mol/l), amrinone had no significant influence on left ventricular pressure or coronary flow (p < 0.05) and epicardial NADH-fluorescence area or infarct size were not significantly affected compared to controls (p > 0.05). Amrinone (5 x 10(-5) mol/l) or milrinone (10(-5) mol/l) significantly increased left ventricular pressure (+10%, p < 0.05) and coronary flow (+30, 40%, p < 0.05) to a similar extent. Concomitantly, both agents similarly reduced epicardial NADH-fluorescence area (-25%, p < 0.05) and infarct size relative to the area at risk or ventricle size compared to controls (p < 0.05).
CONCLUSION:
amrinone or milrinone possess comparable antiischemic effects in isolated rabbit hearts that seem to be related to coronary dilator activity of these agents.
AuthorsA F Rump, B Blazincic, W Klaus
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 43 Issue 12 Pg. 1262-6 (Dec 1993) ISSN: 0004-4172 [Print] Germany
PMID8141811 (Publication Type: Journal Article)
Chemical References
  • Cardiotonic Agents
  • Pyridones
  • NAD
  • Milrinone
  • Amrinone
Topics
  • Amrinone (pharmacology)
  • Animals
  • Cardiotonic Agents (pharmacology)
  • Coronary Circulation (drug effects, physiology)
  • Fluorescence
  • Hemodynamics (drug effects)
  • Histocytochemistry
  • In Vitro Techniques
  • Male
  • Milrinone
  • Myocardial Infarction (pathology, physiopathology)
  • Myocardial Ischemia (pathology, physiopathology)
  • NAD (metabolism)
  • Oxygen Consumption (drug effects, physiology)
  • Pyridones (pharmacology)
  • Rabbits

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