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Intranasal administration of Pasteurella multocida toxin in a challenge-exposure model used to induce subclinical signs of atrophic rhinitis in pigs.

Abstract
A challenge-exposure model was developed for dose-dependent induction of subclinical (moderate) atrophic rhinitis (AR) in conventionally raised Dutch Landrace and Large White pigs, about 4 weeks old. Under favorable climatic and housing conditions, pigs were intranasally challenge-exposed with Pasteurella multocida-derived toxin (Pm-T) 3 days after pretreatment by inoculation with 1% acetic acid. Pigs were challenge-exposed with 1 of the following Pm-T doses: 0 (control), 5, 13, 20, or 40 micrograms of Pm-T/ml of phosphate-buffered saline solution (PBSS), 0.5 ml/nostril/d on 3 consecutive days. Five weeks after challenge exposure, subclinical (moderate) AR status was defined as intermediate conchal atrophy (grade 2 for ventral conchae on a 0 to 4 scale and grade 1 or 2 for dorsal conchae on a 0 to 3 scale, respectively) and perceptible difference in change in brachygnathia superior (cBS) between control and challenge-exposed pigs between the beginning and end of the study. All Pm-T-exposed pigs had nasal damage that was dose-dependent. The higher Pm-T doses resulted in higher ventral conchae atrophy and dorsal conchae atrophy scores. The cBS increased with applied Pm-T dose, resulting in significant (P < 0.05) differences between controls (3.88 mm) and the 13-, 20-, and 40-micrograms Pm-T-treated groups (7.77, 6.58, and 7.98 mm, respectively). In response to the applied dose, weight gain per week for Pm-T-exposed pigs was lower than that of controls after week 3 (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsP M van Diemen, M F de Jong, G de Vries Reilingh, P van der Hel, J W Schrama
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 55 Issue 1 Pg. 49-54 (Jan 1994) ISSN: 0002-9645 [Print] United States
PMID8141495 (Publication Type: Journal Article)
Chemical References
  • Bacterial Proteins
  • Bacterial Toxins
  • Pasteurella multocida toxin
Topics
  • Administration, Intranasal
  • Animals
  • Atrophy
  • Bacterial Proteins
  • Bacterial Toxins (administration & dosage, toxicity)
  • Nose (pathology)
  • Pasteurella Infections (pathology, veterinary)
  • Pasteurella multocida
  • Rhinitis, Atrophic (pathology, veterinary)
  • Swine
  • Swine Diseases

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